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Speeding up Tandem Mass Spectrometry Based Database Searching by Peptide and Spectrum Indexing
Mass Spectrometry Database Searching Peptide Spectrum Indexing
2010/6/30
Database searching is the technique of choice for shotgun proteomics, and to date much research effort has been spent on improving its effectiveness. However, database searching faces a serious challe...
pNovo: De novo Peptide Sequencing and Identification Using HCD Spectra
Peptide Sequencing dentification HCD Spectra
2010/6/30
De novo peptide sequencing has improved remarkably in the past decade as a result of better
instruments and computational algorithms. However, de novo sequencing can correctly interpret only ∼3...
PeakSelect: preprocessing tandem mass spectra for better peptide identification
preprocessing tandem mass spectra peptide identification
2008/12/31
We present a new preprocessing method, PeakSelect, to improve the accuracy and efficiency of
Tandem Mass-Spec peptide (protein) identification. The fundamental difference between noise and fragment i...
Efficient discovery of abundant post-translational modifications and spectral pairs using peptide mass and retention time differences
post-translational modifications spectral pairs peptide mass
2008/12/31
Peptide identification via tandem mass spectrometry is the basic task of current
proteomics research. Due to the complexity of mass spectra, the majority of mass spectra cannot be interpreted at pres...