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Study of Protein Structures Using Matrix-Assisted Laser Desorpion/Ionization Mass Spectrometry
MALDI In-source decay Hydrogen-attachment dissociation
2009/6/9
The mechanism of in-source decay (ISD) under matrix-assisted laser desorption/ionization (MALDI) conditions has been described. The ISD characteristic is the formation of c- and (z+2)-ions originated ...
Nano-Processing of Transparent Materials by Focussed Femtosecond Laser Pulses for the Development of Novel Bio-Microchip
Femtosecond laser Silica glass Chemical etching
2009/6/8
We report fabrication of three-dimensional (3-D) microchannels inside transparent materials. The 3-D microfabrication was achieved by two steps. First, femtosecond pulses were focussed into the transp...
Time and Frequency Domain Investigations on Ultrafast Photoreaction Dynamics of Photoactive Yellow Protein（PYP）
Photoactive Yellow Protein (PYP) Fs fluorescence spectroscopy Resonance Raman spectroscopy
2009/6/8
Low frequency vibrations of the native PYP and related systems in solution have been investigated in "time" (fs fluorescence up-conversion) and "frequency" (resonance Raman) domains to elucidate their...
Research on the Control of Growth/Differentiation of Tissue Stem Cells; Possible Applications of Laser Technology for the Understanding of Inductive Tissue Regeneration
Fregenerative medicine Stem cell Differentiation
2009/6/8
In addition to infectious diseases, life-style related diseases become a more common reason for medication of elderly people than ever. Dysfunction of organs is an underlying cause of these diseases. ...
Optical Kerr Gate Technique for Ultrafast Fluorescence Spectroscopy of Photoactive Proteins
Optical Kerr gate Time-resolved fluorescence Ultrafast spectroscopy
2009/6/8
A measurement system for ultrafast time-resolved fluorescence spectroscopy was constructed based on electronic Kerr effect. Suitable Kerr medium was searched among glasses and isotropic single crystal...
Preface to Special Issue on Laser Nano Processing toward Protein Modules: From Nano ssembling to Micro Multiplication
Laser Nano Processing Protein Modules Nano ssembling Micro Multiplication
2009/6/8
Preface to Special Issue on Laser Nano Processing toward Protein Modules: From Nano ssembling to Micro Multiplication.
We present experimental results on optical properties of cranial bone controlled by administration of propylene glycol and glycerol. Both transmittance and reflectance spectra of human and porcine cra...
Biophotonics
photonics optical biosciences biotechnologies
2008/12/19
The application of innovative optical technologies in medicine, biology, agriculture, environmental sciences, and public health has emerged as one of the new paradigms in today's knowledge economy. Th...
激光与光电子技术在生物组织光学特性测量中的应用及其医用新技术
激光 生物组织 光电子
2008/9/23
该项目主要内容包括：创建生物组织光学新体系，开拓人体组织光学性质的新测定方法和新技术。激光荧光法肺癌定位的彩色视频图像技术与系统，采用“共轴微光－荧光肺癌诊断和定位仪器”技术，研制激光荧光法肺癌定位彩色视频图像装置。激光血管外照射技术与仪器，开拓激光血管外照射治疗技术，完成治疗用激光剂量参数的活体测量，研制半导体激光治疗机。组织光学体系独创性的构建与论述以及测定人体组织光学性质的新方法与新技术，为...
OCT技术在发育生物学中的应用
光学相干层析技术 发育生物学 生物组织 成像
2008/9/23
基于光学低相干反射测量而发展起来的光学相干层析技术（ Optica1 Coherence Tomography,OCT）是一种新型的成像技术，它可以对强散射介质如生物组织实施非侵入性的快速活体成像。与传统的组织切片相比,OTC可以大大减少对发育形态成像所需的时间、复杂程度及成本。非接触和非侵入式的成像方式有助于研究个体发育中由基因变异所引起的形态和功能变化，因而在发育生物学的研究当中有着广阔的应...
THz关键技术及其在生物医学中的应用
THz THz辐射 THz探测 THz成像
2008/9/23
THz电磁辐射的关键技术就是THz的产生和检测.本文分别介绍了两种产生THz辐射的方法及其对应的检测方法,较为全面地论述了THz成像技术,详细分析了THz成像技术的成像装置、成像原理及成像过程,并对其在生物医学方面的应用前景进行了重点分析.
准分子激光眼屈光度矫正治疗机
准分子激光 眼屈光度矫正 激光应用
2008/8/25
近视、远视和散光等是最常见的屈光异常。激光角膜消融成形术(PRK)利用高能量光子切断角膜组织分子的化学健，将角膜中央的表面进行消融清除，从而修正屈光度，达到矫正视力的目的。利用氟化氩准分子激光(波长为193nm)进行眼角膜屈光度修正，是目前国际上最先进且可靠的激光眼科治疗技术。因为人眼角膜对193nm波长有很好的吸收，紫外激光与角膜组织产生化学作用，几乎不产生热损伤，而且手术精细准确，无手术痕迹与...
准分子激光心血管成形专用设备
激光 激光应用 手术器械 心脏血管疾病
2008/8/7
准分子激光心血管成形专用设备的各项技术指标达到八五攻关合同书的各项技术指标。该设备结构新颖、激光输出稳定可靠，激光脉宽达150ms，光纤耦合效果良好，整机具有自检、自显和可控等功能。单脉冲能量116mj，光纤输出29-58mj，能量不稳定度2.53%，单次充气寿命10^6脉冲数。该课题于92年12月成功地完成一例临床血管成形手术。
漫射近似在测量生物组织光学性质中的适用范围
漫射近似 Monte Carlo模拟 生物组织
2008/7/31
漫射近似理论经常被用来作为测量生物组织光学特性参数实验和方法的理论基础,但是漫射近似理论只是一种对辐射传输理论的近似结果,在一定条件下有其特定的适用范围.为了确定漫射近似理论在活体非侵入式无损测量要求下的适用范围,本文采用Monte Carlo模拟校验的方法,对漫射近似理论和Monte Carlo模拟计算的结果进行了比较,给出了基于单散射反照率a和各向异性因子g的漫射近似理论适用范围数值标准.这一...